an efficient green synthesis of highly substituted imidazoles catalyzed by al-mcm-41 nanoreactors
نویسندگان
چکیده
al-mcm-41 nanoreactors is found to be a remarkable efficient catalyst for one-pot multicomponent cyclocondensation of benzil, aniline or ammonium acetate and aromatic aldehydes for the synthesis of polysubstituted imidazoles under solvent-free conditions. the reaction was efficiently promoted by 10 mg nano-al-mcm-41 and the heterogeneous catalyst was recycled for four runs in this reaction without losing its catalytic activity. the key advantages of this process are operational simplicity, reusable catalyst, shorter reaction time, convenient work-up procedures, avoiding the use of organic solvents and purification of products by non-chromatographic methods. by this advantage, several polysubstituted imidazoles as pharmaceutical important molecules can be prepared in high yield and high purity.
منابع مشابه
An efficient green synthesis of highly substituted imidazoles catalyzed by Al-MCM-41 nanoreactors
Al-MCM-41 nanoreactors is found to be a remarkable efficient catalyst for one-pot multicomponent cyclocondensation of benzil, aniline or ammonium acetate and aromatic aldehydes for the synthesis of polysubstituted imidazoles under solvent-free conditions. The reaction was efficiently promoted by 10 mg nano-Al-MCM-41 and the heterogeneous catalyst was recycled for four runs in this reaction with...
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عنوان ژورنال:
iranian chemical communicationناشر: payame noor university (pnu)
ISSN 2423-4958
دوره
شماره Articles in Press 2016
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